E-biology
Through our e-Biology program, we make our knockout mouse lines available for purchase to academic and non-profit researchers conducting non-commercial research. We estimate that our knockout mouse line resources represent more than half of all genes in the mammalian genome and believe it is the largest collection of its kind. Along with each knockout mouse line purchased, we provide gene specific genotyping protocols and detailed information describing the site of the mutation and the construct used (including restriction map).

Purchasing Mouse Lines
Please complete the form below if you are interested in determining the availability of a mouse line for purchase. You will be contacted within three (3) business days by an e-Biology scientist to discuss the availability of your selected mouse gene. Please note that submission of this request in no way obligates you to the purchase of, or Lexicon to sell such, knockout mouse lines.

e-Biology knockout mouse lines are being offered under standard terms with fees starting at $30,000 per mouse line depending upon the contract options selected.

Request Materials

Selected references from academic clients who have used our knockout mouse lines.

• Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour. J Neurochem. 2006 Nov
  

• UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Mol Cell Biol. 2006 Oct

• Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling. Mol Cell Biol. 2006 Oct

• BAG3 deficiency results in fulminant myopathy and early lethality. Am J Pathol. 2006 Sep

• Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol. 2006 Aug

• Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity.  Hum. Genet., 2006 June.

• Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A. 2006 May.

• Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. J Biol Chem. 2006 Mar

• A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). Mech Dev. 2006 Mar

• Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. J Neurosci. 2006 Mar

• Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J Clin Invest. 2006 Mar

• A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy. Embo J. 2006 Feb

• Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals. Biochem Biophy Res Commun. 2006 Jan

• MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan

• Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol. 2005 Dec

• R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat Med. 2005 Dec

• RLIP76 is a major determinant of radiation sensitivity. Cancer Res. 2005 Jul

• N-cadherin is not essential for limb mesenchymal chondrogenesis. Dev Dyn. 2005 Feb

• The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am J Pathol. 2005 Feb

• Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. Biochem Biophys Res Commun. 2004 Dec

• Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo. Circ Res. 2004 Oct

• Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse.  Nature Genetics, 2004 Sept.

• Mouse embryonic fibroblasts derived from Odin deficient mice display a hyperproliiferative phenotype. DNA Res. 2004 Aug

• BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell. 2004 Aug

• Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci. 2004 Jul

• A new role for Nogo as a regulator of vascular remodeling. Nat Med. 2004 Apr

• BUBR1 deficiency results in abnormal megakaryopoiesis. Blood. 2004 Feb

• Phosphodiesterase 7A-deficient mice have functional T cells. J Immunol. 2003 Dec

• The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses. Curr Biol. 2003 Oct

• Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol. 2003 Feb

• Severe retinal degeneration associated with disruption of semaphorin 4A Invest Ophthalmol Vis Sci. 2004 Aug
  

• Phosphodiesterase 7A-deficient mice have functional T cells. J Immunol. 2003 Dec

• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov
  

• MDMX is a negative regulator of p53 activity in vivo. Cancer Research, 2002 Jun.

• Full-speed mammalian genetics: in vivo target validation in the drug discovery process. Trends Biotechnol., 2002 Jan.

• Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice. Physiol Genomics., 2001 Dec.

• In vivo drug target discovery: identifying the best targets from the genome. Curr Opin Biotechnol., 2001 Dec.

• Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol., 2001 Jul.

• Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature, 1998 Apr.

• Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. J Neurosci. 2006 Feb

• Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint. Immunity. 2006 Jan

• Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes. 2005 Dec

• GABARAP is not essential for GABA receptor targeting to the synapse. Eur J Neurosci. 2005 Nov

• Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005 Oct

• Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. J Biol Chem. 2005 Sep

• Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Mol Cell Bio. 2005 Sep
  

• Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise. J Biol Chem. 2005 Apr

• The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. Cell. 2005 Jan 28
  

• Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. Mol Cell Biol. 2004 Sep

• Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat Genet. 2004 Sep

• Abnormal cardiac development in the absence of heart glycogen. Mol Cell Biol. 2004 Aug

• Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro. Hum Mol Genet. 2004 Jul

• Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Bio. 2004 Jun

• Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol. 2004 May

• Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation. J Biol Chem. 2004 Mar

• Intron disruption of the annexin IV gene reveals novel transcripts. J Biol Chem. 2003 Oct

• Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Mol Cell Biol. 2003 Sep

• Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev. 2003 Sep

• Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci USA 2003 May.

• Axon Regeneration in Young Adult Mice Lacking Nogo-A/B Neuron. 2003 Apr.

• Characterization of the WAVE1 knock-out mouse: implications for CNS development. J Neurosci. 2003 Apr

• Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 2003 Apr.
  

• Role for the BRCT protein 53BP1 in maintaining genomic stability. J Biol Chem 2003 Apr.

• The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol 2003 Feb.

• Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development Molecular and Cellular Biology, 2002 Aug

• p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc Natl Acad Sci USA 2002 Jun.

• Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest., 2002 Apr.

• Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol., 2001 May.